Abstract Background This case report presents the case of a patient with P369S and R408Q variants in the MEFV gene who exhibited clinical features of Kikuchi disease and Mollaret meningitis. Furthermore. it discusses colchicine as a new potential treatment option for Kikuchi disease-associated meningitis. Case presentation A 41-year-old Japanese woman presented with fever and headache. https://jalyttlers.shop/product-category/lamp-shade/