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The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells. and mutated FOXL2 causes the blepharophimosis. ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and revealed its antagonism of Sox9. https://www.roneverhart.com/Dudley-ASA-Thunder-ZN-Hycon-12-52-300-Softballs-4A-068Y/
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